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A total of 3 % of active compound is excreted in urine as unchanged Lively compound. Tapentadol is Furthermore metabolised to N-desmethyl tapentadol (13 %) by CYP2C9 and CYP2C19 and also to hydroxy tapentadol (2 %) by CYP2D6, which are even more metabolised by conjugation. For that reason, active compound metabolism mediated by cytochrome P450 proc